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The South-Western Polytechnic was opened at Manresa Road, Chelsea, in 1895, to provide scientific and technical education to Londoners. Day and evening classes for men and women comprised study in domestic economy, mathematics, engineering, natural science, art and music. It was renamed the Chelsea Polytechnic in 1922. The Polytechnic taught a growing number of registered students of the University of London, and this relationship was later formally recognised when the renamed Chelsea College of Science and Technology was admitted as a School of the University in 1966. Government of the College was devolved to the so-called Governing Body, supplemented from its inception in 1961 by an Academic Board reflecting the interests of staff and students. These were renamed the Council and Senate when the College was granted its Royal Charter in 1971. The College Secretary was senior administrative officer until the merger of Chelsea with King's College and Queen Elizabeth College in 1985.

The South-Western Polytechnic was opened at Manresa Road, Chelsea, in 1895, to provide scientific and technical education to Londoners. Day and evening classes for men and women comprised study in domestic economy, mathematics, engineering, natural science, art and music. It changed its name to Chelsea Polytechnic in 1922 and taught a growing number of registered students of the University of London, and this relationship was later formally recognised when the Polytechnic, now reconstituted as Chelsea College of Science and Technology, was admitted as a School of the University in 1966. The renamed Chelsea College was formally incorporated into the University of London in 1971. Chelsea merged with King's and Queen Elizabeth College in 1985. The Registry was responsible for the organisation and audit of academic and educational provision throughout the College, most notably in overseeing examinations and academic assessment, and by way of organising ceremonies and graduations.

Chelsea College became a School of the University of London in 1966. Originally founded in 1891 as the South-Western Polytechnic, later Chelsea Polytechnic (1922), the college became a designated college of advanced technology (as Chelsea College of Science and Technology) in 1957. In 1966 the college became a School of the University of London, and in 1971 the renamed Chelsea College was formally incorporated into the University of London. Following the merger in 1985 with King's College London and Queen Elizabeth College, the personnel functions of all three colleges were integrated in a single department which took responsibility for the staff and reported to the College Secretary.

Library provision at the South-Western Polytechnic was restricted to the availability of reading room space. Students were expected to use the adjacent Chelsea Public Library in order to consult books and periodicals. The inconvenience of this arrangement led to the creation of a Library Committee in 1921. The consequent library remained comparatively small until the post-World War Two expansion in provision that witnessed an increase in the number of titles from around 8000 in 1960 to 80,000 in 1970. These were divided between the Main Library, branch libraries situated on the principal College sites, and departmental collections of reference volumes. All of these were combined with the King's Library when the Colleges merged in 1985.

The South-Western Polytechnic was opened at Manresa Road, Chelsea, in 1895, to provide scientific and technical education to Londoners. Day and evening classes for men and women comprised study in domestic economy, mathematics, engineering, natural science, art and music. It changed its name to Chelsea Polytechnic in 1922 and taught a growing number of registered students of the University of London, and this relationship was later formally recognised when the Polytechnic, now reconstituted as Chelsea College of Science and Technology, was admitted as a School of the University in 1966. Government of the College was devolved to the so-called Governing Body, supplemented from its inception in 1961 by an Academic Board reflecting the interests of staff and students. These were renamed the Council and Senate when the College was granted its Royal Charter in 1971. Chelsea College merged with King's and Queen Elizabeth College in 1985 whereupon the functions of the Council and Senate were transferred to the King's Council and Academic Board.

A Liberal Studies Department was first introduced at Chelsea College of Science and Technology in 1958 in order to fulfil a requirement for more broadly based technical qualifications by providing courses in film, music, architectural appreciation, literature, history of science, modern languages and sociology that were open to all students of the College. Liberal Studies changed its name to the Department of Humanities in 1967 and introduced a postgraduate Diploma in Modern Cultural Studies. It also organised extra-curricular activities such as music recitals, drama productions and poetry readings. Its functions were taken over by the Faculty of Arts at King's College when Chelsea and King's merged in 1985.

A social studies course was first introduced in 1941 at the then Chelsea Polytechnic to help train Red Cross and civil defence workers for social work after the war. This led to the creation in 1970 of the Department of Sociology and Psychology that aimed to cover work in social and behavioural sciences, including a postgraduate course in Social Work Studies and a two-year MSc course, which also led to the Certificate of Qualification in Social Work. The Department Sociology and Psychology was closed at the end of 1983.

Physiology was originally part of the Department of Natural Science at Chelsea Polytechnic and, from 1933, the Department of Biology. Instruction in Physiology continued to be provided by this department until 1951, and mostly comprised teaching for the intermediate and final BSc General degree of the University of London. Some instruction was also provided for Pharmacy students, but Physiology constituted only a small part of the course and Pharmacology was not taught. The Department of Physiology was formed in 1952 then, in 1954, the growing importance of Pharmacology was finally acknowledged and a Department of Physiology and Pharmacology was created. This became a major department with an emphasis on evening and part-time classes gradually giving way to more full-time courses. Postgraduate and research courses were provided alongside the BSc Special degree in Physiology. Pharmacology was introduced as a specialised subject for the BPharm, while a Diploma of Technology was instituted in 1958. Physiology and Pharmacology were split into separate departments when Chelsea was incorporated into the University of London in 1966. The Department of Physiology continued at Chelsea College until the merger with King's College London in 1985.

The South-Western Polytechnic (later Chelsea Polytechnic/College) Department of Physics and Mathematics was divided into two separate departments in 1907. Until 1918-1919, much of the work conducted by the department was ancillary to the Departments of Electrical and Mechanical Engineering. These departments were then transferred to Battersea Polytechnic. The Department of Mathematics subsequently developed courses for the General and Special degrees of the University of London. During the Second World War, scientific research development stimulated the need for mathematical education, and shortly after the war, advanced courses were introduced at the request of physicists of the EMI Research Laboratories and GEC Research laboratories that developed into lecture courses for the MSc degree of the University of London. Mathematics teaching was transferred to King's College when King's and Chelsea merged in 1985.

Classes in Physics and Electrical Engineering were made available at the South-Western Polytechnic from 1895. The two disciplines were separated in 1906 and in 1918 the Departments of Electrical and Mechanical Engineering were transferred to Battersea Polytechnic. An Engineering Science course in Electronics was reintroduced in 1967 at the successor to the South-Western/Chelsea Polytechnic, Chelsea College of Science and Technology. This Department of Electronics then merged with King's College London Department of Electronic and Electrical Engineering in 1985. It is now known as the Department of Electronic Engineering, and is part of the Division of Engineering within the School of Physical Sciences and Engineering at King's College London.

The Department of Chemistry traces its origin back to the opening of the South-Western Polytechnic in 1895. Chemistry was initially taught in day classes within the School of Science for Boys and Girls, the Technical Day College for Men and in evening classes. Known as the Chemical Department, it included a metallurgical and pharmaceutical section. In 1927 the Chemical Department was re-named the Department of Chemistry within what was then Chelsea Polytechnic. The work of the department was very diversified and in 1933 the School of Pharmacy became a separate department and in 1939 Metallurgy was transferred to Battersea Polytechnic. Work was seriously disrupted during World War Two and, as in World War One, some of the laboratories were given over for emergency use. In subsequent years, the numbers of full-time students increased rapidly as grant-holding servicemen enrolled and the numbers of full-time research workers also increased. The Polytechnic was designated a College of Advanced Technology in 1957. Changes were made to the constitution of the Board of Governors to provide greater representation to industrial and professional activities. Work below the standard of University degrees including Intermediate teaching was discontinued and the College was renamed Chelsea College of Science and Technology. The Department of Chemistry introduced a sandwich course leading to graduate membership of the Royal Institute of Chemistry, which was discontinued in 1961. In 1966 the College was admitted as a School of the University of London and was renamed Chelsea College. It merged with King's College London and Queen Elizabeth College in 1985 to create King's College London (KQC).